1: Chemical Product Identification

Product Name: Propylene glycol
Catalogue Codes: SLP1162, SLP2974
CAS#: 57-55-6
RTECS: TY2000000
TSCA: TSCA 8(b) inventory: Propylene glycol
CI#: Not applicable.
Synonym:   1,2, -propanediol, 1,2-dihydroxypropane
Chemical Name: Propylene Glycol
Chemical Formula: CH3CHOHCH2OH

2. Composition and Information on Ingredients 

Toxicological Data on Ingredients: Propylene glycol: ORAL (LD50): Acute: 20000 mg/kg [Rat]. 22000 mg/kg [Mouse]. DERMAL (LD50): Acute: 20800 mg/kg [Rabbit].

3: Hazards Identification

Potential Acute Health Effects: Hazardous in case of ingestion. Slightly hazardous in case of skin contact (irritant, permeator), of eye contact (irritant), of inhalation.

Potential Chronic Health Effects: Slightly hazardous in case of skin contact (sensitizer). CARCINOGENIC EFFECTS: Not available.



DEVELOPMENTAL TOXICITY: Not available. The substance may be toxic to central nervous system (CNS). Repeated or prolonged exposure to the substance can produce target organs damage.


4: First Aid Measures

Eye Contact: Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelids open. Cold water may be used. Get medical attention.

Skin Contact: In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove contaminated clothing and shoes. Cold water may be used. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention.

Serious Skin Contact: Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate medical attention.

Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.

Serious Inhalation: Not available.

Ingestion: Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband.

Serious Ingestion: Not available.

5: Fire and Explosion Data

Flammability of the Product:                                                       May be combustible at high temperature.

Auto-Ignition Temperature:                                                        371°C (699.8°F)

Flash Points:                                                                                       CLOSED CUP: 99°C (210.2°F). OPEN CUP: 107°C (224.6°F) (Cleveland).

Flammable Limits:                                                                            LOWER: 2.6% UPPER: 12.5%

Products of Combustion:                                                              These products are carbon oxides (CO, CO2).

Fire Hazards in Presence of Various Substances:                 Slightly flammable to flammable in presence of heat.

Explosion Hazards in Presence of Various Substances:

Risks of explosion of the product in presence of mechanical impact: Not available.

Risks of explosion of the product in presence of static discharge: Not available.

Fire Fighting Media and Instructions:                                       SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet.

Special Remarks on Fire Hazards:                                              When heated to decomposition it emits acrid smoke and irritating fumes.

Special Remarks on Explosion Hazards:                                   Not available.

6: Accidental Release Measures

Small Spill:

Dilute with water and mop up or absorb with an inert dry material and place in an appropriate waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements.

Large Spill:

Absorb with an inert material and put the spilled material in an appropriate waste disposal. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDS and with local authorities.

7: Handling and Storage

Precautions: Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the residue under a fume hood. Ground all equipment containing material. Do not ingest. Do not breathe gas/fumes/ vapor/spray. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoid contact with skin and eyes. Keep away from incompatibles such as oxidizing agents, reducing agents, acids, alkalis, moisture.

Storage: Hygroscopic. Keep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above 23°C (73.4°F).

8: Exposure Controls/Personal Protection

Engineering Controls: Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapours below their respective threshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station location.

Personal Protection: Splash goggles. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.

Personal Protection in Case of a Large Spill: Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self-contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product.

Exposure Limits: TWA: 10 (mg/m3) from AIHA Consult local authorities for acceptable exposure limits.

9: Physical and Chemical Properties

Physical state and appearance:                                                  Liquid. (Oily liquid.)

odour:                                                                                                   Practically Odourless.

Taste:                                                                                                    Practically Tasteless.

Molecular Weight:                                                                           76.1g/mole

Colour: Colourless.                                                                          Clear

pH (1% soln/water):                                                                        Not available.

Boiling Point:                                                                                     188°C (370.4°F)

Melting Point:                                                                                    -59°C (-74.2°F)

Critical Temperature:                                                                     Not available.

Specific Gravity:                                                                                1.036 (Water = 1)

Vapor Pressure:                                                                                0 kPa (@ 20°C) 0.08 mmHg at 20 C 0.129 mmHg at 25 C

Vapor Density:                                                                                   2.62 (Air = 1)

Volatility:                                                                                             Not available.

odour Threshold:                                                                              Not available.

Water/Oil Dist. Coeff.:                                                                   The product is more soluble in water; log(oil/water) =                                                                                     -0.9

Iconicity (in Water):                                                                         Not available.

Dispersion Properties:                                                                    See solubility in water, acetone.

Solubility:                                                                                            Soluble in cold water, hot water, acetone.

10: Stability and Reactivity Data

Stability:                                                                                               The product is stable.

Instability Temperature:                                                               Not available.

Conditions of Instability:                                                               Incompatible materials, excess heat, exposure to moist air or water

Incompatibility with various substances:                                Reactive with oxidizing agents, reducing agents, acids, alkalis.

Corrosivity:                                                                                         Non-corrosive in presence of glass.

Special Remarks on Reactivity:                                                    Hygroscopic; keep container tightly closed. Incompatible with chloroformates, strong acids (nitric acid, hydrofluoric acid), caustics, aliphatic amines, isocyanates, strong oxidizers, acid anhydrides, silver nitrate, reducing agents.

Special Remarks on Corrosivity:                                                  Not available.

Polymerization:                                                                                 Will not occur.

11: Toxicological Information

Routes of Entry: Absorbed through skin. Eye contact.

Toxicity to Animals: Acute oral toxicity (LD50): 18500 mg/kg [Rabbit]. Acute dermal toxicity (LD50): 20800 mg/kg [Rabbit].

Chronic Effects on Humans: May cause damage to the following organs: central nervous system (CNS).

Other Toxic Effects on Humans: Hazardous in case of ingestion. Slightly hazardous in case of skin contact (irritant, permeator), of inhalation.

Special Remarks on Toxicity to Animals: Not available.

Special Remarks on Chronic Effects on Humans: May affect genetic material (mutagenic). May cause adverse reproductive effects and birth defects (teratogenic) based on animal test data.

Special Remarks on other Toxic Effects on Humans:

Acute Potential Health Effects:

Skin: May cause mild skin irritation. It may be absorbed through the skin and cause systemic effects like those of ingestion.

Eyes: May cause mild eye irritation with some immediate, transitory stinging, lacrimation, blepharospasm, and mild transient conjunctival hyperaemia. There is no residual discomfort or injury once it is washed away.

Inhalation: May cause respiratory tract irritation.

Ingestion: It may cause gastrointestinal tract irritation. It may affect behaviour/central nervous system(CNS depression, general anaesthetic, convulsions, seizures, somnolence, stupor, muscle contraction or spasticity, coma), brain (changes in surface EEG), metabolism, blood (intravascular haemolysis, white blood cells – decreased neutrophil function), respiration (respiratory stimulation, chronic pulmonary enema, cyanosis), cardiovascular system(hypotension, bradycardia, arrhythmias, cardiac arrest), endocrine system (hypoglycaemia), urinary system (kidneys), and liver.

Chronic Potential Health Effects: Skin: Prolonged or repeated skin contact may cause allergic contact dermatitis. Ingestion: Prolonged or repeated ingestion may cause hyperglycaemia and may affect behaviour/CNS (symptoms like that of acute ingestion). Inhalation: Prolonged or repeated inhalation may affect behaviour/CNS (with symptoms like ingestion), and spleen

12: Ecological Information

Ecotoxicity: Ecotoxicity in water (LC50): >5000 mg/l 24 hours [Goldfish]. >10000 mg/l 48 hours [guppy]. >10000 mg/l 48 hours [water flea].

BOD5 and COD: Not available.

Products of Biodegradation: Possibly hazardous short-term degradation products are not likely. However, long term degradation products may arise.

Toxicity of the Products of Biodegradation: The products of degradation are less toxic than the product itself.

Special Remarks on the Products of Biodegradation: Not available.

13: Disposal Considerations

Waste Disposal:

14: Transport Information

DOT Classification: Not a DOT controlled material (United States).

Identification: Not applicable.

Special Provisions for Transport: Not applicable.

15: Other Regulatory Information

Other Regulations: EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.

Protective Equipment: Gloves. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Splash goggles.

16: Other Information

Other Special Considerations: Not available

References: Not Available


All information and instructions provided in this Material Safety Data Sheet in respect of the substance is given solely in terms of the provisions of the Occupational Health and Safety Act No 85 of 1993

and Regulations (“the Act”), is based on scientific and technical knowledge as at the date indicated on this MS Material Safety Data Sheet and is presented in good faith to be correct.

The information and instructions provided in this MSDS apply only to the substance in its present form and not to any formulation or mix, in which event it is the sole responsibility of the user of the substance as formulated and/or mixed to investigate and establish any danger which may arise out of its use, wherever such user may be situated.

It is the sole responsibility of the person in receipt of this Material Safety Data Sheet wherever such recipient may be situated, to ensure that the information provided is communicated to and understood by any person who may come in contact with the substance in any place and in any manner whatsoever. If such recipient produces formulations or mixes using the substance, then it is such recipient’s sole responsibility to comply with the provisions of the Act in respect of the provision of the necessary Material Safety Data Sheet, or to comply with any other applicable legislation.